Endocrine Abstracts

We have used an androgen receptor knockout (ARKO) mouse model with an in-frame deletion of the 2nd zinc finger of the DNA binding domain, which abolishes the genomic actions of the AR to investigate androgen regulation of fat mass. At 12 weeks of age, ARKO males have increased adiposity compared to wildtype (WT) males, with subcutaneous fat mass increased by 75% (P<0.001, n≥17/group) and infrarenal fat mass increased by 36% (P<0.05, n&...

Kennedy's disease (KD), also known as spinal and bulbar muscular atrophy, is one of eight polyglutamine diseases caused by an expansion of CAG repeats within the coding region of the affected gene. In KD, the CAG repeat region within the androgen receptor (AR) gene is increased to over 40 repeats, resulting in an expanded polyglutamine tract. Degeneration of a sub-population of neurones occurs in all polyglutamine diseases due to a toxic gain of function typically unrelated to...

Sex steroids have complex effects: testosterone predominantly regulates trabecular and estradiol, cortical bone1. Studies in transgender individuals use insensitive technology and report conflicting effects2. We hypothesized estradiol therapy will increase cortical volumetric bone mineral density (vBMD) in male-to-female (MtF) individuals and testosterone therapy will increase trabecular vBMD in female-to-male (FtM) individuals.Aims...

Women’s bone metabolism is regulated by estrogens and interleukins. During the menopausal period the estrogens’ protective activity is decreased and the production of IL1β and IL6 is increased.The aim of the studyThe assessment of the dependency between IL1β i IL6 and estradiol values and BMD and IBM in postmenopausal women.Material: Forty-eight women, age 49–61, without menstruation ...

Introduction: The most frequent clinical manifestations of pituitary macroadenoma include headache, vision disturbances and cranial nerve paralysis.Case study: Thirty-year-old man was admitted to intensive care unit at regional hospital. On admission, he was unconscious, with convulsions, spasms and 3-day long history of headache as well as body temperature up to 41.5 °C. The patient was transferred to the Department of Infectious Diseases, with the...

Introduction/Aim: Diabetic ketoacidosis is a rare complication in type 2 diabetic patients treated with SGLT2 inhibitors; usually there is a triggering factor (major trauma or surgery, sepsis) or misdiagnosis (type 1 diabetes or LADA). Nivolumab is an anti-CD279 monoclonal antibody used as a second-line immunotherapy in non-small cell lung carcinoma; its use has been associated with fulminant type 1 diabetes and other autoimmune endocrine diseases. We hereby present a case of ...

Objective: To determine the prevalence and characteristics of psychiatry inpatients with type 2 diabetes and pre-diabetes, compared to psychiatry inpatients without diabetes.Research design and methods: Inpatients aged >30 years at the Austin psychiatry unit (February 2014–April 2015) had HbA1c measurements as part of the Diabetes Discovery Initiative. Patients were divided into three groups – diabetes (HbA1c ≥6.5%, 48 mmol/mol), pre-...

Background: Androgen deprivation therapy (ADT) for prostate cancer (PCa) leads to a global loss of lean mass. ADT leads to sexual dysfunction and a selective loss of leg muscle function, however individual muscle volumes have never been evaluated. We aimed to assess in men undergoing ADT, the muscle volumes of levator ani, which in mice is androgen-responsive, and of lower-limb muscles.Methods: We conducted a prospective case-control study involving 34 m...

Introduction: Contrast-induced nephropathy (CIN) is an important cause of acute kidney injury (AKI) in inpatients. However, the prevalence and predisposing factors for CIN remain poorly documented. The aim of this study was to investigate the association between CIN, kidney function and diabetic status in inpatients.Methods: We identified inpatients who received IV contrast prior to a computed tomography (CT) scan between July 2012 to March 2018 at Austi...